|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||The antiserum was produced against a chemically synthesized phosphopeptide derived from the region of human PDGFRá that contains tyrosines 572 and 574 and PDGFRâ tyrosines 579 and 581. The sequence is conserved in PDGFRá mouse, rat and frog.|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.3, with 1mg/ml BSA, 50% glycerol|
|Contains||0.05% sodium azide|
PDGFRA is a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. Studies in knockout mice, where homozygosity is lethal, indicate that the alpha form of the platelet-derived growth factor receptor is particularly important for kidney development since mice heterozygous for the receptor exhibit defective kidney phenotypes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Alpha platelet-derived growth factor receptor; Alpha platelet-derived growth factor receptor precursor (PDGF-R-alpha); Alpha-type platelet-derived growth factor receptor; Beta platelet-derived growth factor receptor; Beta-type platelet-derived growth factor receptor; CD140 antigen-like family member A; CD140 antigen-like family member B; CD140a; CD140a antigen; CD140b; kinase PDGFR-beta; MGC74795; PDGF alpha chain; PDGF beta chain; PDGF Receptor alpha; PDGF Receptor beta; PDGF-R-alpha; PDGF-R-beta; PDGFR; PDGFR-1; PDGFR-2; pdgfr-a; PDGFR-alpha; PDGFR-beta; PDGFR2; PDGFRA/BCR fusion; PGFRB; Platelet-derived growth factor alpha receptor; Platelet-derived growth factor receptor 1; Platelet-derived growth factor receptor 2; Platelet-derived growth factor receptor alpha; Platelet-derived growth factor receptor beta; platelet-derived growth factor receptor beta variant 1; platelet-derived growth factor receptor, alpha polypeptide; rearranged-in-hypereosinophilia-platelet derived growth factor receptor alpha fusion protein; RHEPDGFRA
Gene Aliases: AI115593; AI528809; CD140A; CD140b; GAS9; Pdgfr; PDGFR-1; PDGFR-2; Pdgfr1; PDGFR2; PDGFRA; Pdgfrb; RHEPDGFRA
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