|ELISA (ELISA)||Assay Dependent|
|Immunohistochemistry (IHC)||Assay Dependent|
|Western Blot (WB)||Assay Dependent|
|Western Blot (WB)||See 42 publications below|
|Miscellaneous PubMed (MISC)||See 5 publications below|
|Immunohistochemistry - Free Floating (IHC (Free))||See 3 publications below|
|Immunohistochemistry (Paraffin) (IHC (P))||See 8 publications below|
|Immunohistochemistry (IHC)||See 27 publications below|
|Immunocytochemistry (ICC)||See 7 publications below|
|ELISA (ELISA)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Rat , Fruit fly , Hamster , Human , Mouse , Chicken|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Purified human Tau|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MN1060 targets PHF-tau (Thr212/Ser214) in ELISA, IHC, and WB applications and shows reactivity with Human samples.
The MN1060 immunogen is purified human Tau.
MN1060 detects PHF-tau (Thr212/Ser214) which has a predicted molecular weight of approximately 79 kDa.
This product is a Low Endotoxin formulation.
Paired helical filament (PHF) is a major component of the neurofibrillary tangles involved in the pathology of Alzheimer and quote;s disease. PHFs are composed of the microtubule-associated protein tau in a hyper-phosphorylated state (ref1). Tau protein is produced by a single gene expressed predominantly in neurons. The Tau gene undergoes complex alternative splicing, yielding six different isoforms of tau in the adult brain. Following translation, the tau protein can be further modified by phosphorylation at several different sites
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: G protein beta1/gamma2 subunit-interacting factor 1; Microtubule-associated protein tau; microtubule-associated protein tau, isoform 4; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau; protein phosphatase 1, regulatory subunit 103
Gene Aliases: DDPAC; FTDP-17; MAPT; MAPTL; MSTD; MTBT1; MTBT2; PPND; PPP1R103; TAU
UniProt ID: (Human) P10636
Entrez Gene ID: (Human) 4137
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