|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Non-human primate|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide derived from human PTP1B around the phosphorylation site of Ser50 (D-V-SP-P-F)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: EC 22.214.171.124; non-receptor type 1; protein tyrosine phosphatase, placental; Protein-protein-tyrosine phosphatase HA2; Protein-tyrosine phosphatase; Protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; PTP-1B; PTP-HA2; PTPN1; Tyrosine-protein phosphatase non-receptor type 1
Gene Aliases: PTP-1B; PTP-HA2; PTP1B; PTPN1
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