|Western Blot (WB)||Assay Dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic phosphopeptide corresponding to residues surrounding Ser11 of human RCC1 protein|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 50% glycerol, 100µg/ml BSA|
RCC1 is called Regulator of Chromosome Condensation 1. Ran GTPase plays important roles in nucleocytoplasmic transport in interphase and in both spindle formation and nuclear envelope (NE) assembly during mitosis. The latter functions rely on the presence of high local concentrations of GTP bound Ran near mitotic chromatin. RanGTP localization has been proposed to result from the association of Ran's GDP/GTP exchange factor, RCC1, with chromatin , but Ran is shown here to bind directly to chromatin in two modes, either dependent or independent of RCC1, and, where bound, to increase the affinity of chromatin for NE membranes.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cell cycle regulatory protein; CHC1; Chromosome condensation protein 1; guanine nucleotide-releasing protein; RCC1-I; Regulator of chromosome condensation; SNHG3-RCC1; SNHG3-RCC1 readthrough; SNHG3-RCC1 readthrough transcript
Gene Aliases: CHC1; RCC1; RCC1-I; SNHG3-RCC1
UniProt ID: (Human) P18754
Entrez Gene ID: (Human) 1104
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.