|Western Blot (WB)||1:1000|
|Tested Species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr202 of rat SYT1 conjugated to KLH|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, canine, chicken, human, mouse, non-human primate and zebrafish based on 100% sequence homology.
This antibody is specific for the ~60 kDa to 62 kDa Synaptotagmin protein phosphorylated at Ser309 in Western blots of rat brain lysates.
Synaptotagmin is widely regarded as the primary calcium sensor for synaptic vesicle exocytosis (Fernandez-Chacon et al , 2001; Wang et al , 2003). Moreover recent studies indicate that the protein also plays a key role in endocytosis (Poskanzer et al , 2003). Synaptotagmin can be phosphorylated by multiple protein kinases and this may play a key role in modulation of synaptotagmin ability to influence both the exocytotic and endocytotic components of synaptic transmission (Hilfiker et al , 1999; Lee et al , 2004).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: p65; SVP65; synaptotagmin 1; Synaptotagmin I; Synaptotagmin-1; SYT; SytI
Gene Aliases: P65; Syt1
UniProt ID: (Rat) P21707
Entrez Gene ID: (Rat) 25716
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