|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of serine 416 (T-G-S(p)-I-D) derived from Rat Tau.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
A suggested positive control for Western blot is rat brain, rat hippocampus or mouse brain cells.
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N- terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.
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Protein Aliases: MAPT; microtubule-associated protein tau; MTBT1; neurofibrillary tangle protein; paired helical filament-tau; PHF-tau; Tau microtubule-associated protein
Gene Aliases: Mtapt; pTau; RNPTAU
Entrez Gene ID: (Rat) 29477
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