|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Peptide sequence around phosphorylation site of serine 641 (D-D-S(p)-D-F) derived from Human alpha-catenin.|
|Storage buffer||PBS, pH 7.4, with 50% glycerol|
|Contains||0.02% sodium azide|
A suggested positive control for Western blot is Hela cells.
Alpha catenin is a member of the b-catenin family of cytosolic proteins. Alpha catenin interacts with N-cadherin and b-catenin on the cytosolic side of adherins junctions to mediate the interaction with the actin cytoskeleton. Alpha catenin is a homodimer in solution, but dissociates to form a 1:1 heterodimer with b-catenin in order to interact with cadherins. Mice that have a-catenin ablated in their surface epithelium demonstrate reduced hair growth, multinucleated cells, extensive proliferation and a general cancerous phenotype.
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Protein Aliases: 102 kDa cadherin-associated protein; 102kDa; alpha E catenin; Alpha E-catenin; alpha(E)-catenin; alpha-catenin; alpha-E-catenin; alphaE-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; Catenin alpha-1; Renal carcinoma antigen NY-REN-13
Gene Aliases: 2010010M04Rik; AA517462; AI988031; CAP102; Catna1; CTNNA1; MDPT2
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