|Western Blot (WB)||0.3-1 µg/ml|
|Tested Species reactivity||Human, Mouse, Pig|
|Host / Isotype||Goat / IgG|
|Immunogen||Peptide with sequence C-SPSKPVEPLNPKK, from the C-terminus of NPHS2|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
This antibody is predicted to react with cow based on sequence homology.
Podocin (NPHS2 protein) is an important member of a group of proteins shown to be associated with the slit diaphragm. Podocin belongs to the band 7 stomatin family of lipid raft-associated proteins. It is a hairpin like integral membrane protein with intracellular N and C termini. Podocin is located at the insertion site of the slit membrane, and is thought to act as a scaffold protein required to maintain or regulate the structural integrity of the slit diaphragm. It plays a role in the regulation of glomerular permeability, acting probably as a linker between the plasma membrane and the cytoskeleton.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: nephrosis 2 homolog, podocin; nephrosis 2 idiopathic steroid-resistant; nephrosis 2, idiopathic, steroid-resistant (podocin); NPHS2 podocin; PDCN; Podocin; SRN1
Gene Aliases: AI790225; NPHS2; PDCN; SRN1
Molecular Function: cytoskeletal protein
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