|Flow Cytometry (Flow)||1.2 ug/10^6 cells|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Purified human PSG isolated from retroplacental blood.|
|Storage buffer||PBS, pH 7.2|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody recognizes native human PSG protein expressed in transfected mammalian cells.
Human pregnancy-specific glycoproteins (PSG), are a group of closely related secreted glycoproteins which are highly expressed in placental syncytiotrophoblast cells of fetal origin. PSG are commonly expressed in tumors of trophoblast origin (hydatidiform mole, choriocarcinoma). They represent the most abundant fetal protein in the maternal blood at term. The eleven human PSG genes (PSG1-PSG11) form together with the carcinoembryonic antigen (CEA)-related cell adhesion molecule (CEACAM) genes the CEACAM gene family. PSG stimulates secretion of TH2-type cytokines from monocytes. CD9 was shown to represent the monocyte receptor for murine PSG17. PSG are thought to modulate the maternal immune system during pregnancy thus protecting the semiallotypic fetus from rejection.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: B1G1; CD66 antigen-like family member F; CD66f; DHFRP2; Fetal liver non-specific cross-reactive antigen 1/2; FL-NCA-1/2; FLJ90598; FLJ90654; PBG1; pregnancy-specific B-1 glycoprotein; Pregnancy-specific beta-1 glycoprotein C/D; Pregnancy-specific beta-1-glycoprotein 1; PS-beta-C/D; PS-beta-G-1; PSBG1; PSG IIA-d; PSG1; PSG95; PSGGA; PSGIIA-a; PSGIIA-b; PSGIIA-c
Gene Aliases: B1G1; CD66f; DHFRP2; FL-NCA-1/2; PBG1; PS-beta-C/D; PS-beta-G-1; PSBG-1; PSBG1; PSG1; PSG95; PSGGA; PSGIIA; SP1
UniProt ID: (Human) P11464
Entrez Gene ID: (Human) 5669
Molecular Function: cell adhesion molecule cytokine receptor defense/immunity protein immunoglobulin receptor superfamily kinase membrane-bound signaling molecule protein kinase receptor signaling molecule transferase
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