|Western Blot (WB)||3-7 µg/ml|
|Tested Species reactivity||Bovine, Dog, Horse, Human, Marsupial, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (2 NLERVSNEEKLNLCRKYY 19) of Presenilin enhancer protein 2 protein.|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Presenilin enhancer protein 2 (PEN-2) is a part of a gamma-secreted complex which catalyses the final cleavage of amyloid precursor protein to generate the toxic amyloid beta protein, the major component of plaque in the brains of Alzheimer disease patients. It is an essential subunit of the gamma-secretase complex, and an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). And probably represents the last step of maturation of gamma-secretase, facilitating endoproteolysis of presenilin and conferring gamma-secretase activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gamma-secretase subunit PEN-2; hematopoietic stem/progenitor cells protein MDS033; Liver regeneration-related protein LRRGT00140; LRRGT00140 mRNA; MDS033; MSTP064; PEN-2; PEN2; presenilin enhancer 2 homolog; presenilin enhancer gamma secretase subunit; Presenilin enhancer protein 2
Gene Aliases: 1700023M09Rik; BOS_17497; MDS033; MSTP064; PEN-2; PEN2; PSENEN; RGD1312037
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