|Western Blot (WB)||Assay dependent|
|Tested Species reactivity||Human|
|Host / Isotype||Mouse / IgG2a|
|Immunogen||The region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli.|
|Storage buffer||PBS, pH 7.4|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-23268 detects Progesterone receptor in Human samples.
MA1-23268 has been successfully used in Western Blot procedures. A suggested positive control for this product is MCF7.
MA1-23268 immunogen corresponds to the region encoding amino acids 1-101 of the human progesterone receptor expressed in E. coli..
Store at 4°C short term. For extednded storage aliquot and store at -20°C or below, avoiding freeze/thaw cycles.
The human Progesterone Receptor (PgR) is a member of the steroid family of nuclear receptors. PgR is found as a 120 kDa protein (Form B) or a 94 kDa protein (Form A) due to the use of alternative translation initiation sites. In its inactive state, PgR forms a multiprotein complex which includes heat shock proteins and immunophins. Upon binding of progesterone hormone to its receptor, there is a conformational change that allows dimerization and binding of the receptor to progesterone response elements (PRE) sequences, resulting in activated transcription.
Protein Aliases: NR3C3; Nuclear receptor subfamily 3 group C member 3; PR; Progesterone receptor
Gene Aliases: NR3C3; PGR; PR
UniProt ID: (Human) P06401
Entrez Gene ID: (Human) 5241