|Immunohistochemistry (Frozen) (IHC (F))||1:25-1:50|
|Immunohistochemistry (Paraffin) (IHC (P))||1:25-1:50|
|Immunoprecipitation (IP)||2 µg/ml|
|Western Blot (WB)||1 µg/ml|
|Immunocytochemistry (ICC)||See 7 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|ChIP assay (ChIP)||See 2 publications below|
|Western Blot (WB)||See 14 publications below|
|Immunohistochemistry (IHC)||See 32 publications below|
|Gel Shift (GS)||See 1 publications below|
|ELISA (ELISA)||See 1 publications below|
|Tested Species reactivity||Horse, Human, Pig|
|Published species reactivity||Deer , Bovine , Sheep , Cat , Human , Mouse , Chicken , Rhesus monkey|
|Host / Isotype||Mouse / IgG|
|Clone||hPRa2 + hPRa3|
|Immunogen||Human endometrial carcinoma from in athymic mice.|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
MA1-12626 detects Progesterone Receptor in human, equine and porcine samples.
MA1-12626 has been successfully used in immunofluorescence, immunoprecipitation, western blot and immunohistochemistry (paraffin, frozen) procedures.
The MA1-12626 immunogen is human endometrial carcinoma from in athymic mice.
The progesterone receptor is a member of the Steroid Hormone Receptor Superfamily. It exists in two distinct isoforms in human cells. PR-B is the transcriptionally active form and is responsible for activating genes for the maintainence of the endometrium, maintenance of pregnancy, and inhibition of ovulation. PR-A is identical to PR-B except for a 165 amino acid deletion at the N-terminus. This deletion exposes a 140 amino acid inhibitory domain (ID) that acts as a repressor of steroid hormone transcriptional activity. Phospholabeling studies have shown that PR is phosphorylated in at least 9 different locations in response to progestins, which suggests that PR affects many different cellular pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: NR3C3; Nuclear receptor subfamily 3 group C member 3; p4 receptor; PR; Progesterone receptor
Gene Aliases: NR3C3; PGR; PR
UniProt ID: (Human) P06401
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