|ELISA (ELISA)||assay dependent|
|Immunohistochemistry (Paraffin) (IHC (P))||1:1000|
|Tested Species reactivity||Human|
|Host / Isotype||Sheep / IgG|
|Immunogen||Purified human prostate specific antigen from human seminal fluid|
|Contains||0.09% sodium azide|
|Storage conditions||4°C or -20°C if preferred|
Heat-mediated antigen retrieval using a sodium citrate buffer (pH 6.0) is recommended for the staining of paraffin sections. A suggested positive control for immunohistochemical applications is human prostate.
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates several transcript variants encoding different isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Gamma-seminoprotein; hK3; Kallikrein-3; kallikrein-related peptidase 3; KLK2A1; P-30 antigen; prostate specific antigen; Prostate-specific antigen; PSA; Semenogelase; Seminin
Gene Aliases: APS; hK3; KLK2A1; KLK3; PSA
UniProt ID: (Human) G3XAE3
Entrez Gene ID: (Human) 354
Molecular Function: annexin calcium-binding protein calmodulin enzyme modulator hydrolase intracellular calcium-sensing protein peptide hormone protease protease inhibitor receptor serine protease signaling molecule
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