|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 224 of Human Proteasome 20S alpha 4|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28149 targets Proteasome 20S alpha 4 in IF and WB applications and shows reactivity with Human samples.
The PA5-28149 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 224 of Human Proteasome 20S alpha 4.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HC9; HsT17706; Macropain subunit C9; Multicatalytic endopeptidase complex subunit C9; proteasome (prosome, macropain) subunit, alpha type, 4; Proteasome component C9; Proteasome subunit alpha type-4; proteasome subunit HC9; Proteasome subunit L; PSC9
Gene Aliases: HC9; HsT17706; PSC9; PSMA4
UniProt ID: (Human) P25789
Entrez Gene ID: (Human) 5685
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