|Western Blot (WB)||1:1000-1:10,000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 1 and 205 of Human Proteasome 20S beta 3|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 1% BSA, 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28999 targets Proteasome 20S beta 3 in WB applications and shows reactivity with Human samples.
The PA5-28999 immunogen is recombinant fragment corresponding to a region within amino acids 1 and 205 of Human Proteasome 20S beta 3.
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified proteasome, the immunoproteasome, is the processing of class I MHC peptides. This gene encodes a member of the proteasome B-type family, also known as the T1B family, that is a 20S core beta subunit. Pseudogenes have been identified on chromosomes 2 and 12.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: HC10-II; proteasome (prosome, macropain) subunit, beta type, 3; Proteasome chain 13; Proteasome component C10-II; Proteasome subunit beta type-3; Proteasome theta chain
Gene Aliases: HC10-II; PSMB3
UniProt ID: (Human) P49720
Entrez Gene ID: (Human) 5691
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