|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 58 and 242 of Human Protor1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-32185 targets Protor1 in WB applications and shows reactivity with Human samples.
The PA5-32185 immunogen is recombinant fragment corresponding to a region within amino acids 58 and 242 of Human Protor1.
This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: FLJ20185k; PP610; proline rich 5 (renal); Proline-rich protein 5; Protein observed with Rictor-1; PROTOR-1; PROTOR1; prr5; Rho GTPase activating protein 8
Gene Aliases: Arhgap8; AU043908; C030017C09Rik; C78947; FLJ20185k; PP610; PROTOR-1; PROTOR1; PRR5
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