|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic peptide corresponding to residues in human QSER1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 50% glycerol|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 190 kDa.
Purity is >95% by SDS-PAGE.
QSER1 (glutamine and serine-rich protein 1) is a 1,735 amino acid protein that is phosphorylated upon DNA damage, probably by Atm or ATR. A single nucleotide polymorphism (SNP) that is nearly equidistant between the genes QSER1 and PRRG4 on chromosome 11, at just under 20 kb from each, has been suspected of association with Parkinson disease. Existing as two alternatively spliced isoforms, the QSER1 gene is conserved in chimpanzee, canine, bovine, mouse, rat, chicken and zebrafish, and maps to human chromosome 11p13. With approximately 135 million base pairs and 1,400 genes, chromosome 11 makes up around 4% of human genomic DNA and is considered a gene and disease association dense chromosome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are also associated with defects in chromosome 11.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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