|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 6 and 399 of Human RAD21|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28344 targets RAD21 in IHC (P), IF, and WB applications and shows reactivity with Human and mouse samples.
The PA5-28344 immunogen is recombinant fragment corresponding to a region within amino acids 6 and 399 of Human RAD21.
The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad21, a gene involved in the repair of DNA double-strand breaks, as well as in chromatid cohesion during mitosis. This protein is a nuclear phospho-protein, which becomes hyperphosphorylated in cell cycle M phase. The highly regulated association of this protein with mitotic chromatin specifically at the centromere region suggests its role in sister chromatid cohesion in mitotic cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Double-strand-break repair protein rad21 homolog; hHR21; HR21; HRAD21; kleisin; MCD1; Nuclear matrix protein 1; NXP-1; NXP1; Pokeweed agglutinin-binding protein 29; protein involved in DNA double-strand break repair; PW29; RAD21 homolog; SCC1; SCC1 homolog; sister chromatid cohesion 1
Gene Aliases: CDLS4; hHR21; HR21; HRAD21; KIAA0078; MCD1; mKIAA0078; NXP1; RAD21; SCC1
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