|Immunohistochemistry (IHC)||3-6 µg/ml|
|Immunohistochemistry (Paraffin) (IHC (P))||3-6 µg/ml|
|Western Blot (WB)||0.03-0.1 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (NAAEELKPRNKK) corresponding to the C-terminus amino acids of RAE1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
This antibody is predicted to react with bovine, canine, mouse, porcine and rat based on sequence homology.
Mutations in the Schizosaccharomyces pombe Rae1 and Saccharomyces cerevisiae Gle2 genes have been shown to result in accumulation of poly-containing mRNA in the nucleus, suggesting that the encoded proteins are involved in RNA export. The protein encoded by this gene is a homolog of yeast Rae1. It contains four WD40 motifs, and has been shown to localize to distinct foci in the nucleoplasm, to the nuclear rim, and to meshwork-like structures throughout the cytoplasm. This gene is thought to be involved in nucleocytoplasmic transport, and in directly or indirectly attaching cytoplasmic mRNPs to the cytoskeleton. Alternatively spliced transcript variants encoding the same protein have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: dJ481F12.3; dJ800J21.1; FLJ30608; HGNC:9828; homolog of yeast Rae1 (Bharathi) mRNA-associated protein of 41 kDa (Kraemer); MGC117333; MGC126076; MGC126077; MIG14; migration-inducing gene 14; Mnrp41; mRNA export factor; mRNA export protein; mRNA-associated protein MRNP 41; mRNA-binding protein, 41-kD; MRNP41; OTTHUMP00000166110; RAE1; RAE1 (RNA export 1, S.pombe) homolog; Rae1 protein homolog; RAE1 RNA export 1 homolog; RAE1 RNA export 1 homolog (S. pombe); RP4-800J21.2
Gene Aliases: dJ481F12.3; dJ800J21.1; MIG14; Mnrp41; MRNP41; RAE1
UniProt ID: (Human) P78406
Entrez Gene ID: (Human) 8480
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