|Flow Cytometry (Flow)||Assay dependent|
|Western Blot (WB)||2-4 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Fusion protein containing amino acid residues 1-317 of human TRANCE/RANKL.|
|Contains||0.02% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
MA1-20347 detects sRANKL in Human and Mouse samples.
MA1-20347 has been successfully used in FACS and Western blot procedures.
The MA1-20347 immunogen is a fusion protein containing amino acid residues 1-317 of human TRANCE/RANKL.
sRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CD254; hRANKL2; ODF; OPG ligand; OPGL; OPTB2; Osteoclast differentiation factor; Osteoprotegerin ligand; RANKL; receptor activator of NF-kappaB ligand; receptor activator of nuclear factor kappa B ligand; Receptor activator of nuclear factor kappa-B ligand; RP11-86N24.2; sOdf; TNF-related activation-induced cytokine; TNFSF11; TRANCE; tumor necrosis factor (ligand) superfamily member 11; tumor necrosis factor (ligand) superfamily, member 11; tumor necrosis factor ligand 6B; Tumor necrosis factor ligand superfamily member 11; tumor necrosis factor-related activation-induced cytokine
Gene Aliases: CD254; hRANKL2; Ly109l; ODF; OPG; OPGL; OPTB2; RANKL; sOdf; TNFSF11; TNLG6B; TRANCE
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