|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 583 and 834 of Human RASA3|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30445 targets RASA3 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30445 immunogen is recombinant fragment corresponding to a region within amino acids 583 and 834 of Human RASA3.
The protein encoded by this gene is member of the GAP1 family of GTPase-activating proteins. The gene product stimulates the GTPase activity of normal RAS p21 but not its oncogenic counterpart. Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in the inactive GDP-bound form of RAS, thereby allowing control of cellular proliferation and differentiation. This family member is an inositol 1,3,4,5-tetrakisphosphate-binding protein, like the closely related RAS p21 protein activator 2. The two family members have distinct pleckstrin-homology domains, with this particular member having a domain consistent with its localization to the plasma membrane.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: GAPIII; 3; 4; 5)P4-binding protein; 5-tetrakisphosphate-binding protein; GAP1(IP4BP); GAP1IP4BP; GTPase activating protein III; GTPase-activating protein 1 family, inositol 1,3,4,5-tetrakisphosphate-binding protein; inositol 1; Ins P4-binding protein; Ins(1; Ins(1,3,4,5)P4-binding protein; Ras GTPase-activating protein 3
Gene Aliases: GAP1IP4BP; GAPIII; RASA3
UniProt ID: (Human) Q14644
Entrez Gene ID: (Human) 22821
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