|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 20 and 803 of Human RASA4|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-31885 targets RASA4 in IF and WB applications and shows reactivity with Human samples.
The PA5-31885 immunogen is recombinant protein fragment corresponding to a region within amino acids 20 and 803 of Human RASA4.
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Ca2+-promoted Ras inactivator; Calcium-promoted Ras inactivator; CAPRI; GAPL; Ras GTPase-activating protein 4; Ras p21 protein activator 4; RasGAP-activating-like protein 2
Gene Aliases: CAPRI; GAPL; KIAA0538; RASA4
UniProt ID: (Human) O43374
Entrez Gene ID: (Human) 10156
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