|Immunohistochemistry (Paraffin) (IHC (P))||1:1000|
|Western Blot (WB)||2 µg/ml|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide made to an internal portion of the human protein (within residues 210-252).|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 30% glycerol|
|Contains||0.1% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
The target sequence has 92% sequence homology with rat.
The RCAN1 protein interacts with calcineurin A and inhibits calcineurin-dependent signaling pathways, possibly affecting central nervous system development. This gene is located in the minimal candidate region for the Down syndrome phenotype, and is overexpressed in the brain of Down syndrome fetuses. Isoform RCAN1-1L has been shown to be overexpressed in Alzheimer's Disease (Harris, C.D. et al) and is downregulated in Huntington's Disease (Ermak, G. et al).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ADAPT78; calcineurin inhibitor; Calcipressin-1; calcium and oxidant-inducible mRNA; CSP1; Down syndrome candidate region 1; Down syndrome critical region gene 1; Down syndrome critical region protein 1; Down syndrome critical region protein 1 homolog; DSC1; DSCR1; MCIP1; modulatory calcineurin-interacting protein 1; Myocyte-enriched calcineurin-interacting protein 1; near DSCR proline-rich protein; RCN1; Regulator of calcineurin 1
Gene Aliases: ADAPT78; CALP1L; CSP1; DSC1; DSCR1; MCIP1; RCAN1; RCN1
Molecular Function: signaling molecule
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