|Immunohistochemistry (Frozen) (IHC (F))||1:10-1:20|
|Immunohistochemistry (Paraffin) (IHC (P))||1:10-1:20|
|Immunohistochemistry (IHC)||See 3 publications below|
|Immunocytochemistry (ICC)||See 1 publications below|
|Tested Species reactivity||Human|
|Published species reactivity||Human|
|Host / Isotype||Mouse / IgG1|
|Immunogen||Recombinant protein containing the extreme C-terminal cytoplasmic region of the human ret oncoprotein.|
|Contains||0.09% sodium azide|
|Storage conditions||4° C, do not freeze|
MA1-26379 detects Ret from human samples.
MA1-26379 has been successfully used in immunohistochemistry (paraffin) procedures. Positive control: small intestine.
The MA1-26379 immunogen is recombinant protein containing the extreme C-terminal cytoplasmic region of the human ret oncoprotein.
This gene, a member of the cadherin superfamily, encodes one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This gene plays a crucial role in neural crest development, and it can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations in this gene are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma. Two transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their biological validity has not been confirmed. , ,
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Cadherin family member 12; cadherin-related family member 16; CDHF12; CUX1/RET fusion; HSCR1; hydroxyaryl-protein kinase; MEN2A; MEN2B; MTC1; Proto-oncogene c-Ret; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; receptor tyrosine kinase; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); RET receptor tyrosine kinase; RET transforming sequence; RET-ELE1; RET51
Gene Aliases: CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51
UniProt ID: (Human) P07949
Entrez Gene ID: (Human) 5979
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