|Immunohistochemistry (IHC)||5 ug/mL|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid peptide near the carboxy terminusof human RIM2|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
PA5-34557 can be used with blocking peptide PEP-1600.
Rab3-interacting molecules (RIMs) are synaptic proteins necessary for neuronal transmission and plasticity. RIM1 and RIM2 proteins are expressed in overlapping but distinct patterns throughout the brain. While the ablation of either gene was not lethal in mice, the deletion of both resulted in postnatal mortality. This lethality is due to a defect in neurotransmitter release; synapses without RIM proteins can still release neurotransmitters but are unable to do so in response to normal Ca2+ triggers. Like RIM1, RIM2 is thought to be an effector protein for Rab3, binding to Rab3 on synaptic vesicles in a GTP-dependent manner.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: non-small cell lung cancer RimL3a protein; non-small cell lung cancer RimL3c protein; nuclear protein; Rab-3-interacting molecule 2; Rab-3-interacting protein 3; RAB3 interacting protein 3; Rab3-interacting molecule 2; Rab3-interacting protein; regulating synaptic membrane exocytosis 2; Regulating synaptic membrane exocytosis protein 2; RIM 2; RIM2 (CT); RIMS2
Gene Aliases: KIAA0751; OBOE; RAB3IP3; RIM2; RIMS2
UniProt ID: (Human) Q9UQ26
Entrez Gene ID: (Human) 9699
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.