|Immunohistochemistry (Frozen) (IHC (F))||1:250|
|Western Blot (WB)||1:5000-1:10,000|
|Tested Species reactivity||Bovine, Dog, Chicken, Human, Mouse, Pig, Rat, Xenopus|
|Host / Isotype||Mouse / IgG1, kappa|
|Immunogen||Bovine RPE65 microsomal membrane proteins.|
|Storage conditions||4° C, store in dark|
Highly conserved among vertebrate species, RPE65 is a major protein of the retinal pigment epithelium (RPE). RPE65 is essential for the regeneration of rhodopsin in the visual cycle. Mutations in RPE65 are responsible for certain forms of autosomal recessive severe retinal dystrophy, including Leber Congenital Amaurosis (LCA). Loss of function results in a block in retinoid processing required for the synthesis of 11-cis retinal and the accumulation of retinyl esters in the RPE.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: All-trans-retinyl-palmitate hydrolase; BCO family, member 3; LCA2; modifier of retinal degeneration 1; mRPE65; p63; RBP-binding membrane protein; rd12; retinal pigment epithelium 65-like; retinal pigment epithelium abundant protein RPE65; retinal pigment epithelium specific protein 65; retinal pigment epithelium, 65 kDa; Retinal pigment epithelium-specific 65 kDa protein; retinal pigment epithelium-specific protein (65kD); retinal pigment epithelium-specific protein 65kDa; retinitis pigmentosa 20 (autosomal recessive); Retinoid isomerohydrolase; Retinol isomerase; RP20; rpe65 gene for retinal pigment epithelium-specific protein; sRPE65; truncated RPE65
Gene Aliases: 65kDa; A930029L06Rik; BCO3; BOS_3433; LCA2; Mord1; mRPE65; rd12; RP20; RPE65; sRPE65
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