|Western Blot (WB)||2-4 ug/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 14 amino acid peptide from near the amino terminus of human RTP801.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is 293 cell lysate.
PA5-20496 can be used with blocking peptide PEP-0616.
RTP801 was initially identified as a gene induced by DNA damage, and later found to also be regulated by other cellular stresses such as hypoxia and glucocorticoid treatment. Recently, RTP801 has been shown to act as a mediator of tuberous sclerosis complex (TSC)-dependent regulation of the mammalian Target of Rapamycin (mTOR), an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle. In response to energy stress, RTP801 inhibits mTOR function, resulting in dephosphorylation of downstream targets such as ribosomal protein S6 kinase 1 and 4EBP1 and decreasing cell growth. Disregulation of RTP801 may thus contribute to human tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Dexamethasone-induced gene 2 protein; Dig2, REDD-1, REDD1, RP11-442H21.1, RTP801; DNA damage-inducible transcript 4 protein; DNA-damage-inducible transcript 4; DNA-damage-inducible transcript 4 protein; HIF-1 responsive protein RTP801; HIF-1 responsive RTP801; HIF-1 responsive RTP801 (RTP801); Protein regulated in development and DNA damage response 1; REDD-1
Gene Aliases: 5830413E08Rik; AA415483; DDIT4; Dig2; REDD-1; REDD1; RTP801
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