|Immunohistochemistry (Paraffin) (IHC (P))||18 - 72 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 17 amino acid peptide from 2nd extracellular domain of human RXFP2.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Gibbon, Marmoset, Elephant, Panda, Bat, Horse (94%) Monkey, Dog, Pig (88%).
The activity of this relaxin receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP and may also be a receptor for Leydig insulin-like peptide. Expressed in embryonic and adult gonads of males and females, as well in male gubernarculum and in brain. Not detected in kidney, spleen and heart.
Protein Aliases: G protein coupled receptor affecting testicular descent; G-protein coupled receptor 106; G-protein coupled receptor affecting testicular descent; GPR106; GREAT; INSL3R; leucine-rich repeat-containing G protein-coupled receptor 8; Leucine-rich repeat-containing G-protein coupled receptor 8; LGR8; LGR8.1; Relaxin family peptide receptor 2; Relaxin receptor 2; relaxin/insulin-like family peptide receptor 2; RXFP2; RXFPR2
Gene Aliases: GPR106; GREAT; INSL3R; LGR8; LGR8.1; RXFP2; RXFPR2
UniProt ID: (Human) Q8WXD0
Entrez Gene ID: (Human) 122042