|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:100|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A synthetic non-phosphopeptide derived from human Ret around the phosphorylation site of Tyr905 (D-S-YP-V-K)|
|Purification||Antigen affinity chromatography|
|Storage buffer||Dulbecco's PBS, pH 7.4, with 50% glycerol, 150mM NaCl|
|Contains||0.02% sodium azide|
RET, a member of the cadherin superfamily, is one of the receptor tyrosine kinases, which are cell-surface molecules that transduce signals for cell growth and differentiation. This protein plays a crucial role in neural crest development, and the gene can undergo oncogenic activation in vivo and in vitro by cytogenetic rearrangement. Mutations i are associated with the disorders multiple endocrine neoplasia, type IIA, multiple endocrine neoplasia, type IIB, Hirschsprung disease, and medullary thyroid carcinoma.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C-ret; Cadherin family member 12; cadherin-related family member 16; CUX1/RET fusion; EC 22.214.171.124; hydroxyaryl-protein kinase; kinase Ret; Proto-oncogene c-Ret; Proto-oncogene ret precursor; Proto-oncogene tyrosine-protein kinase receptor Ret; rearranged during transfection; receptor tyrosine kinase; Ret gene for receptor tyrosin; ret proto-oncogene (multiple endocrine neoplasia and medullary thyroid carcinoma 1, Hirschsprung disease); Ret proto-oncogene (multiple endocrine neoplasia MEN2A MEN2B and medullary thyroid carcinoma 1 Hirschsprung disease); RET receptor tyrosine kinase; RET transforming sequence
Gene Aliases: c-Ret; CDHF12; CDHR16; HSCR1; MEN2A; MEN2B; MTC1; PTC; RET; RET-ELE1; RET51; RET9
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