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Invitrogen
This Antibody was verified by Cell treatment to ensure that the antibody binds to the antigen stated.
MA3-812 detects retinoid X receptor (RXR) beta from human and mouse tissues. This antibody is specific for the RXR beta isoform and does not cross react with either RXR alpha or gamma.
MA3-812 has been successfully used in Western blot, immunofluorescence, immunoprecipitation and gel shift procedures. By Western blot, this antibody detects an ~50 kDa protein representing RXR beta from transfected Sf9 cells. Immunofluorescence staining of RXR beta in MCF-7 cells overexpressing RXR beta with MA3-812 results in strong nuclear staining. Gel super shift experiments show disruption of vitamin D receptor (VDR)/RXR beta/VDRE (DNA) complex formation when RXR beta was preincubated with MA3-812, yet experiments using THR showed a supershift of the thyroid hormone receptor (THR)/RXR beta heterodimer by this product.
The MA3-812 antigen is recombinant human RXR beta.
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the effects of retinoic acid (RA). This receptor forms homodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. The gene lies within the major histocompatibility complex (MHC) class II region on chromosome 6.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: DADB-100D22.1; MGC1831; MHC class I promoter binding protein; MHC class I regulatory element-binding protein H-2RIIBP; Nuclear receptor subfamily 2 group B member 2; putative retinoid X receptor beta; Retinoic acid receptor RXR-beta; retinoid X receptor; Retinoid X receptor beta; retinoid X receptor, beta; RXR Beta
Gene Aliases: NR2B2; RXRB
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