|Immunohistochemistry (Paraffin) (IHC (P))||1 - 3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 19 amino acid peptide from 2nd extracellular domain of human RHO / Rhodopsin.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Monkey, Mouse, Rat, Rabbit, Pig, Cat, Elephant, Zebra finch (100%).
Photoreceptor required for image-forming vision at low light intensity. Required for photoreceptor cell viability after birth. Light-induced isomerization of 11-cis to all-trans retinal triggers a conformational change leading to G-protein activation and release of all-trans retinal. Abs(max)=495 nm. Rod shaped photoreceptor cells which mediates vision in dim light. Phosphorylated on some or all of the serine and threonine residues present in the C-terminal region. Defects in RHO are the cause of retinitis pigmentosa type 4 (RP4). RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP4 inheritance is autosomal dominant. Defects in RHO are also a cause of retinitis pigmentosa autosomal recessive (ARRP). Also, defects in RHO are a cause of autosomal dominant congenital stationary night blindness 1 (CSNBAD1); also known as rhodopsin-related congenital stationary night blindness. Congenital stationary night blindness is a nonprogressive retinal disorder characterized by impaired night vision and ocular symptoms such as myopia, hyperopia, nystagmus and reduced visual acuity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CSNBAD1; OPN2; Opsin 2; opsin 2, rod pigment; Opsin-2; RHO; Rhodopsin; rod pigment
Gene Aliases: CSNBAD1; OPN2; RHO; RP4
UniProt ID: (Human) P08100
Entrez Gene ID: (Human) 6010
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