|Western Blot (WB)||1:100-1:2000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||portion of amino acids 1-50 of human Rvb1|
|Storage buffer||PBS with 0.05% BSA|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Rvbs have been implicated in human pathologies, including carcinogenesis. For example Rvb1 overexpresssion has been reported in colon carcinoma, and Rvb1 SUMOylation has been shown to increase the proliferation and growth of prostate cancer cells. Rvb1 may also play a role in autoimmunity as high levels of RUVB1 autoantibodies have been detected in the sera of patients with autoimmune diseases including polymyositis/dermatomyosistic and autoimmune hepatitis. The extensive involvement of Rvbs in DNA-associated processes, including their interaction with a wide range of transcription factors, suggests that Rvb dysregulation may be involved in a number of other pathological processes yet to be elucidated.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 49 kDa TATA box-binding protein-interacting protein; 49 kDa TBP-interacting protein; 54 kDa erythrocyte cytosolic protein; ECP-54; ECP54; INO80 complex subunit H; INO80H; NMP 238; NMP238; Nuclear matrix protein 238; PONTIN; Pontin 52; Pontin52; RuvB (E coli homolog)-like 1; RuvB-like 1; RuvB-like AAA ATPase 1; RVB1; TAP54-alpha; TATA binding protein interacting protein 49 kDa; TIH1; TIP49; TIP49A; TIP60-associated protein 54-alpha
Gene Aliases: ECP-54; ECP54; INO80H; NMP 238; NMP238; PONTIN; Pontin52; RUVBL1; RVB1; TIH1; TIP49; TIP49A
UniProt ID: (Human) Q9Y265
Entrez Gene ID: (Human) 8607
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