|Immunofluorescence (IF)||20 ug/mL|
|Western Blot (WB)||1 - 2 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 16 amino acid synthetic peptide near the amino terminus of human SARM|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is Daudi cell lysate.
PA5-34402 can be used with blocking peptide PEP-1444.
Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SARM (SAM and ARM-containing protein), along with other molecules such as TIRP, TRIF, TIRAP, and MyD88, is thought to serve as an adaptor protein for the TLRs that allows for the activation of downstream kinases and NF-Kappa-B, and ultimately the expression of proteins involved in host defense. While SARM has not been conclusively shown to associate directly with TLRs, the presence of a Toll-interleukin-1 (TIR) domain in SARM is consistent with a role as a signaling molecule.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: MyD88-5; SAM domain-containing protein 2; SARM; Sterile alpha and Armadillo repeat protein; sterile alpha and HEAT/Armadillo motif protein, ortholog of Drosophila; Sterile alpha and TIR motif containing 1; Sterile alpha and TIR motif-containing protein 1; Sterile alpha motif domain-containing protein 2; Tir-1 homolog
Gene Aliases: A830091I15Rik; C78606; KIAA0524; MyD88-5; MyD885; SAMD2; SARM; SARM1
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