|Immunohistochemistry (Paraffin) (IHC (P))||1:200|
|Western Blot (WB)||1:1000|
|Tested Species reactivity||Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to residues surrounding Leu35 of mouse SCD1|
|Storage buffer||0.01M HEPES, pH 7.5, with 0.15M NaCl, 100µg/ml BSA, 50% glycerol|
|Contains||<0.02% sodium azide|
It is not recommended to aliquot this antibody.
Stearoyl-CoA desaturase (SCD; EC 184.108.40.206) is an iron-containing enzyme that catalyzes a rate-limiting step in the synthesis of unsaturated fatty acids. The principal product of SCD is oleic acid, which is formed by desaturation of stearic acid. The ratio of stearic acid to oleic acid has been implicated in the regulation of cell growth and differentiation through effects on cell membrane fluidity and signal transduction. Four SCD isoforms, Scd1 through Scd4, have been identified in mouse. In contrast, only 2 SCD isoforms, SCD1 and SCD5, have been identified in human. SCD1 shares about 85% amino acid identity with all 4 mouse SCD isoforms, as well as with rat Scd1 and Scd2. In contrast, SCD5 shares limited homology with the rodent SCDs and appears to be unique to primates (Zhang et al. (1999); Wang et al., 2005).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: acyl-CoA desaturase; Acyl-CoA desaturase 1; asebia; delta(9)-desaturase; Delta(9)-desaturase 1; Delta-9 desaturase 1; delta-9-desaturase; fatty acid desaturase; Fatty acid desaturase 1; OTTHUMP00000020280; predicted protein of HQ0998; Stearoyl-CoA desaturase 1; stearoyl-CoA desaturase opposite strand
Gene Aliases: AA589638; ab; AI265570; Scd; Scd-1; Scd1
UniProt ID: (Mouse) P13516
Entrez Gene ID: (Mouse) 20249
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