|Immunohistochemistry (IHC)||1:300 - 1:2000|
|Western Blot (WB)||1:300-1:2000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit|
|Immunogen||A synthetic peptide from the extracellular domain of human amiloride sensitive sodium channel subunit gamma|
|Storage buffer||whole serum|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
Glycerol (1:1) may be added for additional stability.
Reconstitute in 100ul of sterile water.
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. Heterotetramer of two alpha, one beta and one gamma subunit. A delta subunit can replace the alpha subunit. Interacts with the WW domains of NEDD4, NEDD4L, WWP1 and WWP2. Apical cell membrane; Multi-pass membrane protein. Phosphorylated on serine and threonine residues. Defects in SCNN1G are a cause of Liddle syndrome. It is an autosomal dominant disorder characterized by pseudoaldosteronism and hypertension associated with hypokalemic alkalosis. The disease is caused by constitutive activation of the renal epithelial sodium channel.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: amiloride-sensitive epithelial sodium channel gamma subunit; amiloride-sensitive sodium channel gamma-subunit; Amiloride-sensitive sodium channel subunit gamma; Amiloride-sensitive sodium channel subunit gamma (SCNN1G; ENaC gamma subunit; ENaCG; Epithelial Na(+) channel subunit gamma; gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; PHA1; SCNEG; SCNEG); sodium channe epithelial 1 gamma subunit; sodium channel, non voltage gated 1 gamma subunit; sodium channel, non-voltage-gated 1, gamma subunit; sodium channel, nonvoltage-gated 1, gamma
Gene Aliases: BESC3; ENaCg; ENaCgamma; PHA1; SCNEG; SCNN1G
UniProt ID: (Human) P51170
Entrez Gene ID: (Human) 6340
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