|Immunocytochemistry (ICC)||5 ug/ml|
|Immunofluorescence (IF)||Assay Dependent|
|Western Blot (WB)||5 ug/ml|
|Western Blot (WB)||See 4 publications below|
|Miscellaneous PubMed (MISC)||See 1 publications below|
|Tested Species reactivity||Bovine, Human, Mouse, Rat, Zebrafish|
|Published species reactivity||Rat , Mouse , Human|
|Host / Isotype||Mouse / IgG2a, kappa|
|Immunogen||Bovine Heart Complex II, with traces of Complex III.|
|Storage buffer||HEPES buffered saline|
|Contains||0.02% sodium azide|
|Storage conditions||4° C|
Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: IP; Iron-sulfur subunit of complex II; mitochondrial; PGL4; SDH1; SDH2; SDHIP; succinate dehydrogenase [ubiquinone] iron-sulfur subunit; Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; succinate dehydrogenase complex subunit B; succinate dehydrogenase complex subunit B, iron sulfur (Ip); succinate dehydrogenase complex, subunit B, iron sulfur (Ip)
Gene Aliases: 0710008N11Rik; BOS_2308; CWS2; fj46d06; IP; PGL4; SDH; SDH1; SDH2; SDHB; SDHIP; wu:fj46d06
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.