|Western Blot (WB)||0.1-.3 ug/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (NWDEQFDKENTEER) corresponding to the internal amino acids of SERPINB6|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
The protein encoded by this gene is a member of the serpin superfamily, and ovalbumin-serpin subfamily. It was originally discovered as a placental thrombin inhibitor. The mouse homolog was found to be expressed in the hair cells of the inner ear. Mutations in this gene are associated with nonsyndromic progressive hearing loss, suggesting that this serpin plays an important role in the inner ear in the protection against leakage of lysosomal content during stress, and that loss of this protection results in cell death and sensorineural hearing loss. Alternatively spliced transcript variants have been found for this gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: CAP; Cytoplasmic antiproteinase; DKFZp686I04222; MGC111370; MSTP057; Peptidase inhibitor 6; PI-6; PI6; Placental thrombin inhibitor; protease inhibitor 6 (placental thrombin inhibitor); PTI; serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 6; Serpin B6; serpin peptidase inhibitor, clade B (ovalbumin), member 6; SERPINB6
Gene Aliases: CAP; DFNB91; MSTP057; PI-6; PI6; PTI; SERPINB6; SPI3
UniProt ID: (Human) P35237
Entrez Gene ID: (Human) 5269
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