|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant protein fragment corresponding to a region within amino acids 1 and 160 of Human SETDB2|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30848 targets SETDB2 in WB applications and shows reactivity with Human samples.
The PA5-30848 immunogen is recombinant protein fragment corresponding to a region within amino acids 1 and 160 of Human SETDB2.
Proteins that contain a SET domain, such as SETDB2, modulate gene expression epigenetically through histone H3 (see MIM 601128) methylation. SETDB2 is likely a histone H3 methyltransferase, as it contains both the active site and flanking cysteine residues required for catalytic activity (Zhang et al., 2003 [PubMed 12754510]).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: C13orf4; chronic lymphocytic leukemia deletion region 8; Chronic lymphocytic leukemia deletion region gene 8 protein; CLLD8; CLLL8; Histone-lysine N-methyltransferase SETDB2; KMT1F; Lysine N-methyltransferase 1F; SET domain bifurcated 2
Gene Aliases: C13orf4; CLLD8; CLLL8; KMT1F; SETDB2
UniProt ID: (Human) Q96T68
Entrez Gene ID: (Human) 83852
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.