|Immunofluorescence (IF)||20 ug/mL|
|Immunohistochemistry (IHC)||20 ug/ml|
|Western Blot (WB)||1 ug/mL|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 17 amino acid synthetic peptide near the center of human SGSM1|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is human cerebellum tissue lysate.
PA5-34438 can be used with blocking peptide PEP-1480.
Small G proteins such as RAP and RAB proteins are the key molecules in intracellular signal transduction and vesicle transportation. A novel protein family small G protein signaling modulator (SGSM) consisting of three members SGSM1-3 bind to RAP and RAB family proteins. All three SGSM proteins possess both a RUN domain and a TBC domain. SGSM1 (RUTBC2) is a 1,148 amino acid protein that localizes to the Golgi apparatus and is mainly expressed in the CNS. SGSM1 interacts with RAP and RAB subfamily members of the small G proteins, and function as modulators of RAP and RAB-mediated neuronal signal transduction and vesicular transportation pathways.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: nurr1-interacting protein; RUN and TBC1 domain containing 2; RUN and TBC1 domain-containing protein 2; RUTBC2; SGSM1; Small G protein signaling modulator 1; small G protein signaling modulator 1 protein
Gene Aliases: 2410098H20Rik; AA408781; D5Bwg1524e; E130107M15; KIAA1941; NuIP; RUTBC2; SGSM1
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