|Immunohistochemistry (Paraffin) (IHC (P))||0.3 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Goat / IgG|
|Immunogen||Synthetic peptide sequence (PQPRPRSLASETN) corresponding to the C-terminus amino acids of SH3BP1|
|Purification||Antigen affinity chromatography|
|Storage buffer||TBS, pH 7.3, with 0.5% BSA|
|Contains||0.02% sodium azide|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: 3BP-1; OTTHUMP00000028981; SH3 domain binding protein 1; SH3 domain-binding protein 1; SH3-domain binding protein 1; SH3BP1
Gene Aliases: ARHGAP43; SH3BP1
UniProt ID: (Human) Q9Y3L3
Entrez Gene ID: (Human) 23616
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