|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Recombinant fragment corresponding to a region within amino acids 310 and 545 of Human SH3MD2|
|Purification||Antigen affinity chromatography|
|Storage buffer||0.1M tris glycine, pH 7, with 20% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-30779 targets SH3MD2 in IHC (P) and WB applications and shows reactivity with Human samples.
The PA5-30779 immunogen is recombinant fragment corresponding to a region within amino acids 310 and 545 of Human SH3MD2.
This gene encodes a protein containing an N-terminus RING-finger, four SH3 domains, and a region implicated in binding of the Rho GTPase Rac. Via the RING-finger, the encoded protein has been shown to function as an ubiquitin-protein ligase involved in protein sorting at the trans-Golgi network. The encoded protein may also act as a scaffold for the c-Jun N-terminal kinase signaling pathway, facilitating the formation of a functional signaling module.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase SH3RF1; plenty of SH3 domains; Plenty of SH3s; POSH; Protein POSH; putative E3 ubiquitin-protein ligase SH3RF1; RING finger protein 142; RING-type E3 ubiquitin transferase SH3RF1; RNF142; SH3 domain-containing RING finger protein 1; SH3 multiple domains 2; SH3 multiple domains protein 2; SH3MD2
Gene Aliases: KIAA1494; POSH; RNF142; SH3MD2; SH3RF1
UniProt ID: (Human) Q7Z6J0
Entrez Gene ID: (Human) 57630
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