|Western Blot (WB)||1-5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to human SIAH-1.|
|Purification||Antigen affinity chromatography|
|Contains||0.08% sodium azide|
|Storage conditions||-80° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is human brain lysate.
Seven in absentia homolog 1 (SIAH-1) is a member of the RINGfinger- containing E3 ubiquitin ligases. Alpha-synuclein and synphilin-1 are substrates of SIAH-1. Both proteins are involved in the development of Parkinson's disease (PD). Mutations in Parkin, another E3 ubiquitin ligase which ubiquinates synphilin-1 and glycosylated alpha-synuclein, have been defined as a major cause of autosomal recessive PD. The role of SIAH-1 in PD is highlighted by the fact that SIAH-1 is a component of the Lewy bodies and plays a role in apoptosis caused by nitric oxide (NO) induced oxidative stress.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: E3 ubiquitin-protein ligase SIAH1; hSIAH1; HUMSIAH; RING-type E3 ubiquitin transferase SIAH1; Seven in absentia homolog 1; Siah-1; Siah-1a
Gene Aliases: HUMSIAH; SIAH1; SIAH1A
UniProt ID: (Human) Q8IUQ4
Entrez Gene ID: (Human) 6477
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