|Immunohistochemistry (Paraffin) (IHC (P))||1:100-1:1000|
|Western Blot (WB)||1:500-1:3000|
|Tested Species reactivity||Human, Mouse|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to a region within amino acids 980 and 1042 of Human SIPA1|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7, with 40% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA5-28122 targets SIPA1 in IF and WB applications and shows reactivity with Human and mouse samples.
The PA5-28122 immunogen is synthetic peptide corresponding to a region within amino acids 980 and 1042 of Human SIPA1.
The product of this gene is a mitogen induced GTPase activating protein (GAP). It exhibits a specific GAP activity for Ras-related regulatory proteins Rap1 and Rap2, but not for Ran or other small GTPases. This protein may also hamper mitogen-induced cell cycle progression when abnormally or prematurely expressed. It is localized to the perinuclear region. Two alternatively spliced variants encoding the same isoform have been characterized to date.
Protein Aliases: GTPase-activating protein Spa-1; p130 SPA-1; signal-induced proliferation-associated gene 1; Signal-induced proliferation-associated protein 1; Sipa-1; SPA1
Gene Aliases: SIPA1; SPA1
UniProt ID: (Human) Q96FS4