|Western Blot (WB)||2 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide between amino acids 300-355 of the human SIRT6 protein.|
|Purification||Antigen affinity chromatography|
|Storage buffer||tris citrate, pH 7-8|
|Contains||0.1% sodium azide|
|Storage conditions||4° C, do not freeze|
PA1-16957 is specific for the ~39 kDa SIRT6 protein.
A higher molecular weight band at ~59 kDa may be seen with lower dilutions such as 2 ug/ml.
Suggested positive control: antigen standard for SIRT6 (transient overexpression lysate), Hela whole cell extract.
Sirtuins regulate epigenetic gene silencing. SIRT6 (Mono-ADP-ribosyltransferase sirtuin-6), a mouse Sir2 homolog, is a chromatin-associated nuclear ADP-ribosyltransferase protein. It appears to be involved in DNA repair and may also play a role in human ageing.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Mono-ADP-ribosyltransferase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; Regulatory protein SIR2 homolog 6; Silent information regulator 2-like protein 6.; SIR2-like protein 6; sir2-related protein type 6; sirtuin type 6
Gene Aliases: SIR2L6; SIRT6
UniProt ID: (Human) Q8N6T7
Entrez Gene ID: (Human) 51548
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