|Western Blot (WB)||1-5 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Polyclonal antibody from rabbits immunized with a synthetic peptide region of human SKIIP|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS with 2% sucrose|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
PA1-24457 detects SkiP in Human samples.
PA1-24457 has been successfully used in Western Blot procedures.
PA1-24457 immunogen corresponds to Polyclonal antibody from rabbits immunized with a synthetic peptide region of human SKIIP.
SKIIP (Nuclear Protein SkiP, nuclear receptor coactivator NCoA-62, ski-interacting protein) is a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also interact with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: homolog of Drosophila BX42; Nuclear protein SkiP; Nuclear receptor coactivator NCoA-62; nuclear receptor coactivator, 62-kD; PPS; SKI interacting protein; SKI-interacting protein; SKIP; SNW domain-containing protein 1
Gene Aliases: Bx42; NCOA-62; Prp45; PRPF45; SKIIP; SKIP; SNW1
UniProt ID: (Human) Q13573
Entrez Gene ID: (Human) 22938
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