|Immunohistochemistry (Paraffin) (IHC (P))||10 µg/ml|
|Tested Species reactivity||Human|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic 19 amino acid peptide from internal region of human SLC39A6.|
|Purification||Antigen affinity chromatography|
|Contains||< 0.1% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C|
Percent identity with other species by BLAST analysis: Human, Gorilla (100%) Orangutan, Monkey (95%) Gibbon, Marmoset (89%).
The zinc transporter ZIP6, also known as SLC39A6, is a member of a family of divalent ion transporters. Zinc is an essential ion for cells and plays significant roles in the growth, development, and differentiation. ZIP6 was initially identified as LIV-1, an estrogen-regulated gene that has been implicated in metastatic breast cancer. Elevated ZIP6 expression has also been reported in human cervical cancer and the HeLa cell line; down-regulation of ZIP6 expression in HeLa by RNAi inhibited cell proliferation, colony formation, migration and invasiveness, as well as decreasing Snail and Slug levels, suggesting ZIP6 plays a regulatory role on the ERK1/2-Snail/Slug pathway.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Estrogen-regulated protein LIV-1; LIV-1; LIV-1 protein, estrogen regulated; LIV1; SLC39A6; solute carrier family 39 (metal ion transporter), member 6; solute carrier family 39 (zinc transporter), member 6; Solute carrier family 39 member 6; Zinc transporter ZIP6; ZIP-6; ZIP6; Zrt- and Irt-like protein 6
Gene Aliases: LIV-1; LIV1; SLC39A6; ZIP6
UniProt ID: (Human) Q13433
Entrez Gene ID: (Human) 25800
Molecular Function: transporter
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