|Western Blot (WB)||1:5,000|
|Tested Species reactivity||Bovine, Chicken, Human, Rat|
|Host / Isotype||Mouse / IgG2b|
|Immunogen||Recombinant human alpha SNAP.|
|Storage buffer||PBS, pH 7.5, with 50% glycerol|
|Storage conditions||-20° C, Avoid Freeze/Thaw Cycles|
A suggested positive control for this product is rat brain lysate.
SNAPs (soluble NSF attachment proteins), acting in concert with SNAREs ( SNAP receptors) and the N-ethylmaleimide-sensitive fusion protein (NSF) are required for the fusion of transport vesicles to their target membranes in synaptic transmission, intra-Golgi transport, endosome-toendosome fusion and transcytotic vesicles-to-plasma membrane transport. Vesicle-to-target membrane docking (initial contact) occurs when the vesicle SNARE binds to its cognate target membrane SNARE. a-SNAP (or b-SNAP in brain) then binds to this docking complex and mediates the binding of NSF and thus the formation of a 20S fusion particle. It is thought that, once NSF is bound, ATP hydrolysis by NSF initiates the fusion process.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: alpha soluble NSF attachment protein; alpha-SNAP; Alpha-soluble NSF attachment protein; N-ethylmaleimide sensitive fusion protein attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein alpha; N-ethylmaleimide-sensitive factor attachment protein, alpha; NAPA; resistance to inhibitors of cholinesterase 4 homolog; SNAP-25; SNAP-alpha; SNAP25; SUP; Super protein; synaptosomal associated protein-25; Synaptosomal-associated 25 kDa protein; Synaptosomal-associated protein 25; Synaptosomal-Associated Protein alpha/beta; synaptosomal-associated protein, 25 kDa; synaptosomal-associated protein, 25kDa; synaptosome associated protein 25kDa
Gene Aliases: alpha-SNAP; bA416N4.2; BOS_12772; BOS_17742; CMS18; dJ1068F16.2; NAPA; RIC-4; RIC4; SEC9; SNAP; SNAP-25; SNAP-25a; SNAP-25B; SNAP25; SNAPA; SUP
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