|Immunohistochemistry (Paraffin) (IHC (P))||5-10 µg/ml|
|Western Blot (WB)||1-3 µg/ml|
|Tested Species reactivity||Human, Marsupial, Mouse, Non-human primate, Rat, Zebrafish|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide (80 KDERKRLAQQNPDLHNAEL 98) of SOX17 protein.|
|Purification||Antigen affinity chromatography|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
SOX17, also known as transcription factor SOX-17, as the name suggests is a transcription factor or a probable transcriptional activator in the premeiotic germ cells. It belongs to the SRY-related HMG box family of transcription factors with a high-mobility group DNA-binding domain (HMG box), that plays a key role in embryogenesis and binds to the sequences 5'-AACAAT-'3 or 5'-AACAAAG-3'. SOX17 plays an essential role in cardiac mesoderm specification as well as in definitive hematopoiesis, maintaining fetal hematopoietic stem cells, hematopoiesis in the fetal liver and yolk sac. Along with beta-catenin, it is known to cooperate in the regulation of transcription of endodermal genes. Defects in SOX17 are known to cause a severe defects in fetal hematopoiesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: SRY (sex determining region Y)-box 17; SRY box 17; SRY-box 17; SRY-box containing gene 17; SRY-related HMG-box transcription factor SOX17; Transcription factor SOX-17; VUR3
Gene Aliases: Sox-17; SOX17; VUR3
If an Invitrogen™ antibody doesn’t perform as described on our website or datasheet, we’ll replace the product at no cost to you, or provide you with a credit for a future purchase.*
Get expert recommendations for common problems or connect directly with an on staff expert for technical assistance related to applications, equipment and general product use.