|Immunohistochemistry (Paraffin) (IHC (P))||1:50-1:200|
|Western Blot (WB)||1:500-1:1000|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||Synthetic peptide corresponding to amino acids 120-170 of human Sox8|
|Purification||Antigen affinity chromatography|
|Storage buffer||PBS, pH 7.2|
|Contains||0.05% sodium azide|
|Storage conditions||Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.|
This antibody detects endogenous protein at a molecular weight of 47 kDa.
Purity is >95% by SDS-PAGE.
Sox genes comprise a family of genes that are related to the mammalian sex determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. Sox genes encode putative transcriptional regulators implicated in the decision of cell fates during development and the control of diverse developmental processes. The highly complex group of Sox genes cluster at a minimum of 40 different loci that rapidly diverged in various animal lineages. At present 30 Sox genes have been identified, and members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: ragged; SOX17; SOX18; SOX8; SOX9; SRY (sex determining region Y)-box 17; SRY (sex determining region Y)-box 18; SRY (sex determining region Y)-box 8; SRY (sex determining region Y)-box9; SRY (sex-determining region Y)-box 9 protein; SRY box 17; SRY box 18; SRY box 8; SRY box 9; SRY-box containing gene 17; SRY-box containing gene 18; SRY-box containing gene 8; SRY-box containing gene 9; Sry-related HMG-box gene 18; SRY-related HMG-box transcription factor SOX17; SRY-related HMG-box, gene 9; Transcription factor SOX-17; Transcription factor SOX-18; Transcription factor SOX-8; Transcription factor SOX-9
Gene Aliases: 2010306G03Rik; AI385749; AV220920; CMD1; CMPD1; HLTRS; HLTS; mKIAA4243; Ra; Ragl; Sox-17; Sox-18; Sox-8; Sox-9; SOX17; SOX18; SOX8; SOX9; SRA1; SRXX2; SRXY10; VUR3
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