|Immunocytochemistry (ICC)||20 ug/ml|
|Immunofluorescence (IF)||20 ug/ml|
|Immunohistochemistry (IHC)||5 µg/ml|
|Western Blot (WB)||0.25 µg/ml|
|Tested Species reactivity||Human, Mouse, Rat|
|Host / Isotype||Rabbit / IgG|
|Immunogen||A 13 amino acid peptide from near the amino terminus of human SRPX1.|
|Purification||Antigen affinity chromatography|
|Contains||0.02% sodium azide|
|Storage conditions||Maintain refrigerated at 2-8°C for up to 3 months. For long term storage store at -20°C|
A suggested positive control is SK-N-SH cell lysate.
PA5-20843 can be used with blocking peptide PEP-0957.
SRPX1 was initially identified as a candidate gene for X-linked retinitis pigmentosa and is overexpressed in the trabecular network of the eye in glaucoma conditions. Its expression is significantly downregulated in a number cancer cell lines and malignant tumor tissues and its ectopic expression induces apoptosis through the endoplasmic reticulum and the activation of caspase-12, -9, and -3, indicating that it can function as a tumor suppressor. SRPX1 is also involved with the regulation of autophagy under low serum conditions and can associate with Rab24, a member of the Rab GTPase protein family that is involved in autophagy. This association of SRPX1 with Rab24 is enhanced during autophagy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Protein Aliases: Down-regulated by v-SRC; DRS; DRS protein; DRS, ETX1, SRPX1; epididymis secretory sperm binding protein Li 83p; Sushi repeat-containing protein SRPX; sushi-repeat containing protein, X-linked; Sushi-repeat-containing protein SRPX; sushi-repeat-containing protein X chromosome; sushi-repeat-containing protein, X chromosome; sushi-repeat-containing protein, X-chromosome; sushi-repeat-containing protein, X-linked
Gene Aliases: DRS; drs-1; drs-2; ETX1; HEL-S-83p; mDRS-1; mDRS-2; SRPX; SRPX1
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